Thursday, May 30, 2013

Possible Neurobiological Basis For Persistent Pain After Stressful Events

Possible Neurobiological Basis For Persistent Pain After Stressful Events

A fresh study led by University of North Carolina School of Medicine researchers is the first to identify a genetic risk agent for persistent pain after traumatic events of the like kind as motor vehicle collision and sexual invasion.

In addition, the study contributes farther on evidence that persistent pain after stressful events, including motor vehicle collisions and sexual assaults, has a characteristic biological basis. A manuscript of the study was published online against us of print by the journal Pain.

"Our study findings indicate that mechanisms influencing chronic trouble development may be related to the stress response, rather than any specific prejudice caused by the traumatic event," related Samuel McLean, MD, MPH, senior first cause of the study and assistant professor of anesthesiology. "In other language, our results suggest that in some individuals something goes wrong with the body's 'fight or flight' response or the body's recovery from this response, and steady pain results."

The study assessed the role of the hypothalamic-pituitary adrenal (HPA) line of rotation, a physiologic system of central weightiness to the body's response to stressful events. The study evaluated whether the HPA line of revolution influences musculoskeletal pain severity six weeks later motor vehicle collision (MVC) and sexual fall upon. Its findings revealed that variation in the gene encoding as antidote to the protein FKBP5, which plays an important role in regulating the HPA shaft response to stress, was associated with a 20 percent higher risk of diminish to severe neck pain six weeks about a motor vehicle collision, as well because a greater extent of body affliction. The same variant also predicted increased vexation six weeks after sexual assault.

"Right since, if an someone comes to the juncture department after a car accident, we don't have any interventions to prevent chronic pain from developing," McLean related. Similarly, if a woman comes to the pass department after sexual assault, we own medications to prevent pregnancy or sexually transmitted illness, but no treatments to prevent chronic pain. This is because we make out what causes pregnancy or infection, only we have no idea what the biologic mechanisms are that give rise to chronic pain. Chronic pain after these events is indifferent and can cause great suffering, and there is an urgent need to be apprised what causes chronic pain so that we be possible to start to develop interventions. This study is every important first step in developing this understanding."

"In addition, because we don't conceive what causes these outcomes, individuals through chronic pain after traumatic events are ofttimes viewed with suspicion, as if they are form up their symptoms for financial win to or having a psychological reaction," McLean before-mentioned. "An improved understanding of the biology helps with this stigma," McLean said.

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.

Article of the Day

This Day in History

Blog Archive